Sunspark
When Intel drivers are set to spatial dithering on a 6-bit panel (NOT temporal!), and you scroll down on a page, even a "still" spatial dithering pattern can cause photos to slightly flicker as you scroll.
This is because the image "interweaves" with different parts of the pattern as the image moves downwards, causing the pattern to appear like it's alternating back and forth, even though the pattern itself "technically" doesn't change.
On most e-ink screens like BOOX, it's even "worse" as the pattern itself regenerates in a very obvious way whenever there is movement, even though it's still when there's no motion. (This might be a solvable problem in the future, as I've heard the Modos open source e-ink monitor project implemented a different dithering method that tries to keep the pattern still…)
However, there's an interesting situation (especially if the display is a TN) where I've observed the "checkerboard pattern" created by spatial dithering at times having the side effect of "accidentally increasing LCD polarity pixel inversion flicker" in that area -- depending on the pattern -- as the checkerboard sometimes lines up with the same kinds of conditions that cause LCD inversion to be visible.
This kind of "accidental pixel inversion" means a spatial dithering pattern can occasionally still increase flicker(!) even if the pattern is not supposed to "intentionally" be changing!
Finally, Intel's version of spatial dithering sometimes decides to slightly alter the hue of a pixel to increase precision further even on grayscale content (the reason why they do this is that adding a slight color can "perceptually affect brightness" in a more fine-grained way). This is distracting to me because sometimes different gray shades in a UI can subtly look reddish or bluish when they're all supposed to "just be gray".
If the panel is good, I agree that spatial dithering is generally fine in most cases and it doesn't cause that much of an issue (especially compared to temporal) but there are still reasons to disable it.
In my case, I prefer disabling it because I have my screen set to grayscale often and I get distracted by the subtle color tints on certain shades of gray.
The flickering while scrolling as a photo interweaves with the pattern also definitely becomes noticeable enough at times to become annoying (especially when I'm scrolling very slowly)