Personally I just finished my Windows safety-check and found these (with old monitors and nVidia driver 528.02):
Win10 21H2 is completely safe for me
Win10 22H2 makes some eyestrain already, which is bad after longer usage
Win10 22H2 KB5051974 from Feb.2025 makes even more eyestrain, i can see/feel the difference when toggling this KB
Win11 all versions are making the highest level of eyestrain, right from the first (21H2) version
Tell me this is not an experiment from M$… Well whatever, because they all can do whatever they want without control.
Other than that, monitors after somewhere like 2017 and newer nVidia drivers are making the high level eyestrain themselves already.