macsforme
I don't fully understand how this works, but I experimented a few times by removing my monitor's color profile from macOS (my monitor BenQ GL2450 is 6bit+FRC). After doing this, it becomes harder for me to focus on the text, as if my eyes want to "slip away" from it (for me, this is always a sign of increased dithering). After a couple of hours of work, my eyes get very tired. If I restore the profile, then these issues did not occur.
While working on disabling dithering in 6-bit mode in Linux, I used the BenQ GL2450 monitor. I discovered that adding a color profile reduced eye strain when switching to 6-bit mode (without dithering at the kernel level).
Also, I felt more comfortable working with an 8-bit+FRC monitor connected to my Mac (BenQ BL2711U monitor), as my eyes felt less strained. However, this doesn’t apply to my TV, which is also 8-bit+FRC. I can use the TV with the same level of comfort as a monitor, both with and without a profile. With both devices, I set 8 bits in BetterDisplay.
I can't say for sure what exact mechanisms are at play here. Therefore, the best way is to try both options: with the profile and without it. Then choose the better one.