Gurm So far only newer computers have caused my eye strain. About 2 years ago I upgraded my original Xbox One to and S and haven't had an issue except for Borderlands 2 from the Handsome Jack collection. I played the original Borderlands 2 on Xbox 360 years ago with no issue but when playing the Xbox one version I couldn't play more than a few minutes without eye strain and a headache.
Someone mentioned a switch earlier in the thread so I'll also add, I'm able to play Switch in handheld and TV mode without issue. I'm playing on a 2017 65" Samsung series 8 LED TV.