I'm getting some interesting results from W10 v2004. The most recent version of Windows I could use for hours on end was Windows 10 v1511, as this seems to work with my temporal dithering / subpixel rendering sensitivity which causes migraines and nausea. To use 1511 I need graphics adapters disabled, run ditherig.exe on my Dell XPS 15 9560 (Intel 630 & Nvidia 1050ti graphics).
Yesterday I installed the latest Windows 10 version 2004 (build 19041.264) as a test, keeping all drivers the same and graphics adapters enabled - basically how a 'standard user' would install. Windows has not felt so comfortable for me in many years. It's way too early to draw any conclusions but I'm interested in other people's experiences.
I used my computer for 1 hour on day 1 as it was the evening, and I've now been using it for 5 hours non-stop and I have no eye strain so far. This is with all graphics adapters enabled (for the first time in years), and still running ditherig.exe as I was before (although I'm not sure this does anything). Other than that I've not tweaked anything.
For reference, these are the drivers I'm using:
Intel Date: 21/04/2017
Intel Driver: 184.108.40.20664
Nvidia Date: 16/03/2018
Nvidia Driver: 220.127.116.1125
**Update - 12 days later, these drivers are working perfectly for me (see post 103)**
Intel Date: 17/06/2016
Intel Driver: 18.104.22.16875
Nvidia Date: 15/05/2020
Nvidia Driver: 22.214.171.12414
Like I said, it's too early to draw any conclusions but it's a very promising start for me at least. Really hope others have a similar experience - I'll update this thread with any findings.