- Edited
So something interesting happened, i decided to update my BIOS on my EVGA Z490 Dark motherboard to test if a newer BIOS would allow me any more overclocking headroom and once i upgraded from version 1.07 released on 9/28/2020 to version 1.10 released on 11/11/2021 i started to experience eyestrain with my Quadro RTX 4000, even the BIOS screen had the strange smeared/glossy/blurry look that other bad cards ive tested had. I flashed the BIOS back to version 1.07 and everything went back to normal and is comfortable. I recommended anyone battling with a bad card to flash and test the entire range of BIOSes available for the motherboard.
Maybe this could be caused by the GOP of the motherboard BIOS interacting with the GOP modules on the GPU in different ways and some work better with certain models of GPU's than others.
https://winraid.level1techs.com/t/gop-update-and-extraction-tool-nvidia-only/91381/
https://winraid.level1techs.com/t/amd-and-nvidia-gop-update-no-requests-diy/30917/923?page=36
https://ledstrain.org/d/261-what-works-for-you-what-do-you-use-now-without-problems/187
My current Quadro RTX 4000 BIOS has UEFI version 5000B, i also found an older bios version of my card that has UEFI version 5000A, and a new version that has version 5000D. I bet if i wanted to use the newer z490 dark bios i could update my UEFI GOP and it would be normal.
And here is a screenshot of a Quadro K4200 Kepler based GPU which is using UEFI version 1002F.
In a case where it was not possible to make a bad GPU comfortable by testing various different motherboard bios versions it would certainly be worth a try changing GOP versions in the GPU's vbios until a comfortable one is found.