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Cozzyb The popular tricks that people use - greyscale and reduce white point - help to ease the discomfort a bit. Essentially what these tricks do are reducing the amplitude of light modulation (dithering of all phones, and PWM of those with OLED screens) so that we perceive less flickering.
Unfortunately it is not enough to make the problem go away because the dithering and PWM are still there. So if you are on iOS 15 backwards, just hold on to it. Don’t update.