whystrainwhy So is it possible that some GPUs and monitor combinations are handling it better than others?
I think, yes
My z690 ( I have 2 pcs ) with 2022 year BIOS or newest one, gives eye-strain with all GC I tried ( 1060, 2070s, 3080, 3080 ti ) with old or new nvidia drivers.
But without GC, using iGPU only - no issues at all. It seems PCI-E 5.0 have some troubles, but I read here troubles with same lga1700 chipset motherboard but with 12400f - it have PCI-E 4.0 slot
So, issue is in motherboard. Ppl also got eye-strain after monitor change with same PC build ( I think issue is in software brightness level model called ~ T-PWM ).
Also some of them got eye-strain after GC change only ( 1060 to 3070 )
Maybe old MB's had color render in 8bit only, when in new modern MB or GC or monitors - they use wide gamut & 10bit. I also read how microsoft present CCCS as wide colorspace where each program upscale color to this colorspace and then downscale to monitor colorspace / colordepth can accept. In theory, all up/downscalers need powerfull GPU or they can use fast math models ( float 16bit half preceision instead of 32bit single precision ) and dithering to smooth banding