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I have MacBook Pro 2017. It causes severe symptoms with default setup in 20 min. Now I have it almost usable — not as easy for eyes as old laptops, but tolerable.
1) Main tune is SwitchResX app (20$). It allows you to set screen to "Million of Colors" (instead of billion) and 1440x900 resolution (not scaling ratio, but real 2x resolution reduction: you will see pixels again). Laptop is still absolutely usable for any kind of work with these settings (I'm designer). Without this app next 6 items make not much difference.
2) Turn off touch-bar: it has very low PWM frequency (I use free MTMR app instead. It allows you to use gestures for tuning brightness and volume with no display at all). Turn off keyboard backlight for the same reason
3) I always have brightness on 70-100% to avoid main display using PWM (as per notebookchek.net tests). Not sure this really changes something, but I do it. For dimming display I use free QuickShade dimmer app
4) I have matte screen protector for reducing glare
5) I have "computer glasses" (Zeiss) for reducing blue light. The do it gently not making all your work yellow. Night shift is always off — I feel that it makes it worse for my eyes, not better
6) Font smoothing is off
7) Color profile is set to a bit lower contrast
Hope this may help