Yep, I instantly noticed eye strain and fatigue when I went from 14.6 to 14.7 and beyond, iOS 15 included. I have no idea what they did, but there's definitely something different flicker-wise. I was unable to use my 8+ and iPad 7th Gen without these issues.
My solution was to go on eBay and buy an iPhone 8+ and iPad 7th Gen on 14.6 or lower, that's unfortunately the only answer right now.