AGI I tried this (I was sitting in a well-lit room with my "patching glasses" and went to a completely dark room), and didn't experience anything unusual.
Another thing that I've noticed, is that if I'm using my computer in the dark and cover my non-dominant eye completely (that no light reaches it at all) then I start getting very strange visual artifacts in my non-covered eye. My vision becomes grainy (something similar to an old TV static), but that graininess appears in waves. Very unusual feeling.
It disappears though if I cover only the lens and my "covered" eye receives some light from the environment.