What I use:
- Windows 10 Home, Ubuntu 22.04, Manjaro 21.3, latest updates.
- Asus Prime H410M-A, the latest bios.
- Intel i5-10400F (without integrated GPU)
- PNY Nvidia Quadro T600 with mini displayport to VGA adapter and mini displayport to hdmi adapter.
- Two monitors: very old AG Neovo F-417 on VGA and ViewSonic VP2458 on hdmi. No problems with F-417 at all. ViewSonic has adjusted settings to make it bearable: brightness 0, contrast 45, color range Full (the same setting in Nvidia settings), color temp Warm and low gamma 1.8, no blue light reduction (it's a marketing trick).
- Latest Nvidia drivers 517.40. Without Nvidia Experience. Linux also uses Nvidia proprietary drivers.
- Mini display port to VGA adapter StarTech MDP2VGA2.
- Mini display port to HDMI adapter Assmann GmbH.
Eye problems are less pronounced on Windows than on Ubuntu. On Ubuntu I usually switch to VGA for both monitors or work just with F-417. For some reason, Ubuntu causes no problems with this monitor and this setup. Manjaro is the most comfortable with ViewSonic on hdmi connection.