It's a work computer, so I can't downgrade the OS.
It has an identical video card as I have in a Win 7 computer that is used without eye strain, so I'm prety sure Windows 10 is the issue.
Windows 10 appears to render type and color completely differently. This seems to cause the monitor to act in a way that causes eye strain. I'm currently working on getting admin access to the machine so I can tweak more settings and see if I can resolve the issue.