hayder1983 which ATI card did you have before?
AMD GPU's
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RX 580 ARMOR 8G. I used Dvi only. I had an LG wtp227pf. I had never eye pain with it. Never noticed dithering, but perhaps it was there. Not sure.
a month later
a month later
Found an interesting website about testing dithering 
What do you think?
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I went from Nvidia to AMD 6700 because I saw something online where someone said they got a PC with a 6600 and it was ok, I couldnt find a 6600 so got a 6700 instead.
Good Nvidia:
1060, 1660s,
Bad Nvidia (so far no setting changes could make these usable on 4 different monitors)
2060, 3060ti
1050ti (possibly bad hardly any use)
The 6700 using display port with AMD software slightly reduced brightness, contrast and saturation (talking default is 100 took it down to 90 sort of thing) and it OK on desktop and some applications.
Example, on my 1660s everything is ok apart from some games.
On the 6700 some common games are ok, but ones that were not on the 1660s are now ok, but ones that were ok on the 1660s are now not.
I do not know why this is. the 6700 must be processing some things differently with newer game engines perhaps.
12 days later
reaganry Tested an AMD HP W5700 Pro Card under Linux and Windows 11, both configurations unfortunately gave me eyestrain. Even with an Old Firepro 2460 off Ebay I experienced eyestrain. Patching my right eye eliminates it.
Only my laptop with an HD4000 gives me no eyestrain even without patching.
A few months have passed, unfortuantely I made the mistake of updating drivers and it immediately was bad, caused migraine like symptoms.
I reverted back to previous drivers / backups but I didnt take a proper full image of the working setup so its back to how it was before even at desktop it causes me issues.
I dont know what setting I was able to change, I have been through all my notes but I may have to try another card now.
10 days later
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I did, but had to contact the 3rd party manufacturer of the card and they told me drivers dont update firmware etc.
It seems you cannot contact AMD support like is possible with Nvidia.
The new driver took FPS down by about 100, reverting didnt make much difference but then the games I was testing have all updated since so that could also affect things, but the output is no longer the same as it was before even with all the same hardware and a resotrepoint.
I used DDU to uninstall drivers and then reinstall. I may try again on a new installation of Windows just to try.
If I can ever get used to it again / set it as it was before I will take a full image, its my fault for not doing that.
Longshot, but same cable as last time? Chroma can be affected by lack of bandwith causing colors to bleed into each other to save bandwith.
20 days later
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Are there any known eye strain problems with AMD Ryzen "G" CPUs? They are the CPUs that have an integrated GPU. I wonder if the integrated GPU could be turned off in case of eye strain and be replaced with a known-safe separate graphics card as last resort. Or is this a case where the separate graphics cards video output always runs through the CPU, potentially inheriting bad output from the CPU?
Forgot to mention: I plan on using Linux.
KM Are there any known eye strain problems with AMD Ryzen "G" CPUs
I haven't tested that and I don't know of any other empirical tests unfortunately.
I wonder if the integrated GPU could be turned off in case of eye strain and be replaced with a known-safe separate graphics card as last resort. Or is this a case where the separate graphics cards video output always runs through the CPU, potentially inheriting bad output from the CPU?
It generally is possible to disable the integrated GPU on most desktop motherboards. As an aside the practice of dedicated GPUs being run through the integrated connection is usually just a feature on laptops and requires a specific system design to implement.
a month later
I bought an AMD Ryzen 5600G APU. The "G" means the CPU has a graphics chip integrated (similar to the usable PlayStation 4 Slim AMD chip, which was one reason I even considered buying this). I have been using it for 2 weeks now on Linux Debian Xfce with specific settings. Looks promising, but I must test it for a few more weeks to be sure. There was small initial eye strain. If there is eye strain left right now after 2 weeks, it is not debilitating. I will continue to use this PC as a daily driver and am ready to push through any (small) eye strain. I did previously push trough the small Nvidia GT 710 (1st gen) Linux eye strain, which took some months but then it kinda went away. I believe this is somehow an eye muscle issue, so being exposed to small eye strain (of the type where it hurts one eye immediately, while not being too strong) seems to have a muscle training effect, perhaps similar to eye patching which some users claim has helped them in the long term. However, there may be video driver settings that are a no-go as with the previous Nvidia card. "TearFree" seems to be one of them. Again, need more testing. However, I wanted to drop this information because it may be worth a try for people who desperately need a recent CPU/GPU. I'm not interested in Windows anymore, so I won't be testing Windows for now. The amdgpu driver was not active by default. It required some setup, like adding non-free and non-free-firmware apt repos. IIRC there was steady eye strain (left eye, as usual when the eye strain is only pixel-related) until the driver was set up properly. As I have pushed through Nvidia Linux eye strain for over a year, I cannot say if I'm already trained in this regard. I still have the same issues with flickering lights as before. So if the training did anything, it just helped with (small) pixel eye strain but not with the debilitating issues of PWM, flickering LEDs/headlights/monitors etc.
There's a lot of AMD driver updates coming through including some colour management support. I'm looking forward to seeing how it looks on my steam deck when they release that big OS update (newer drivers) and it will also have firmware updates as well so a lot will change.
In its current state, it is useable if I need to. Except I don't want to. 
I like my Win10 setup on the other machine, feels easier to work with, including the interface.
So yeah I will be updating to see how it is.
Lots of AMD driver stuff to read here, you can try the DDX one if you are using x.org: https://wiki.archlinux.org/title/AMDGPU