Wallboy Hi there, welcome.
I have tested out Linux distros for years. The main reason I never switched to Linux was due to the eye strain. I had issues as far back as 2007, when testing out distros I would notice the display seemed a bit 'harsher' compared to (then) Windows XP. In hindsight I got the same symptoms that I get now with any OS using dithering. After 10 minutes eyes feel heavy and something just feels 'wrong' about the output.
Before I discovered this forum, "What's wrong with me?" came to mind a lot. If this forum didn't exist and nobody else had these symptoms, at that point I would consider something psychologically wrong with me. Thank god there is a community here, we're not the ones with the problem.
Dithering in a nutshell is the rapid (very rapid) adjustment of adjacent color values to simulate the color in-between which cannot ordinarily be displayed. So when we use any OS with dither (specifically temporal dithering) every pixel is changing color values constantly. IMO this constant noise on the screen, albeit not always noticable, is affecting us. I remember as a kid staring at white noise on a TV (hey, it was the 80's and no world wide web ) and while I didn't get headaches from it, I instinctively knew I couldn't watch that for hours. Same with dithering, I don't think it's healthy for that type of stimulus to be on our screens. Obviously by nature screens have a level of flicker (I always avoided 60hz CRT's and went to 75hz+) but it never caused the severe reactions that I get in this decade.
I would get an eye test just to rule out any other issue, but things such as dithering and the effects, are a very new idea, not recognised by any official authority as bad, and also no user-controllable way to disable (yet).