Serotonin is inhibitory neurotransmitter that activate parasympathetic system which make pupils constricted and more sensitive to lite.flickering.
Thus @Seagull approach to serotonins make sense.
The other point is oculomotor nerve compression due to pressure - https://ledstrain.org/d/3143-found-the-root-cause-of-my-led-eye-strain-and-an-effective-treatment-plan